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Pharmaceutical filling machine solutions provider-Pharmaceutical Liquid Filling Equipment

We are consistently committed to supporting clients to design and build clean workshops, pharmaceutical turnkey project with worriless solutions.

Clean room turnkey project solution provider-cleanroom manufacturer&supplier

Cleanroom project means blocking out and excluding all the pollutants such as microparticles, harmful air, bacteria, etc, within a certain space, reasonably distribute the overall plant structure in the area to meet the requirements of the production process; and controls the temperature, humidity, cleanliness, space height, room pressure, airflow velocity, airflow distribution, noise, vibration, electric distribution, lighting, static electricity, etc, in the effective space(cleanroom) within a certain area of requirements. It' s a specially designed room.

pharmaceutical filling machine solution provider - cleanroom for filling line

We are consistently committed to supporting clients to design and build clean workshops, pharmaceutical turnkey project with worriless solutions.

Pharmaceutical Engineering project solution provider & manufacturer

We are consistently committed to supporting clients to design and build clean workshops, pharmaceutical turnkey project with worriless solutions.

Pharmaceutical industry turnkey project solution provider -production workshop

We are consistently committed to supporting clients to design and build clean workshops, pharmaceutical turnkey project with worriless solutions.

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3+
Production Base

20+
Years’ rich Experience

60+
Projects in 60 Countries

300+
Loyal Clientele

Marya is a sterile pharma filling total solutions provider,

Specializing in the manufacture of pharmaceutical machinery, cleanroom projects, water treatment systems, and liquid preparation systems. With three factories and a team of experts and technicians boasting over 20 years of experience in the pharmaceutical and medical industries, Marya has successfully partnered with pharmaceutical companies and governmental authorities in 55 countries.
Our expertise encompasses factory construction and securing GMP and FDA certifications. We are dedicated to our clients' success, ensuring they enjoy a worry-free and satisfying experience. Our commitment lies in helping clients design and provide high-standard customized aseptic pharmaceutical engineering solutions.

What We Can Do

Shanghai Marya own the ability to provide a perfect solution in the whole pharmaceutical or cleanroom project.

Cleanroom Solution

The one stop solution for cleanroom means blocking out and excluding all the pollutants such as microparticles, harmful air, bacteria, etc, within a certain space, reasonably distributing the overall plant structure in the area to meet the production process requirements. Cleanroom is a specially designed room, cleanroom solution needs to control the temperature, humidity, cleanliness, space height, room pressure, airflow velocity, airflow distribution, noise, vibration, electric distribution, lighting, static electricity, etc, in a cleanroom. No matter how the external air condition changes, the cleanroom's cleanliness, temperature and humidity, pressure, and other performance characteristics can all be maintained and ensure the original design and environmental protection requirements.

Injection Solution

The application plan of the overall solution for aseptic small volume preparations specifically includes a series of fully automated production equipment and information management system for the production of sterile drugs such as vials of powder injection/fluid injection, ampoules, cartridges, pre-filling needle, BFS,etc, and it realized the deep integration of information technology and manufacturing technology, so as to creat a digital and intelligent manufacturing factory; this kind of equipment focus on the fields of high value-added biological drugs and anti-tumor drugs, etc, It has high flexibility and can meet the flexible production demands of batch drug production of pharmaceutical companies or the alternate production of multiple kinds of drugs.

IV Fluid Solution

Known as Large Volume Parenteral (LVP), which usually refers to liquid sterilization preparations with a volume greater than or equal to 50ml and directly injected into the body by intravenous drip, the packaging forms include glass bottle, plastic bottle, non-PVC soft bag and vertical soft bag and other packaging forms; large infusion, tablets, liquid injections, powder injections and capsules are collectively referred to five important preparations in the global pharmaceutical industry. According to its clinical use, large infusions can be divided into fluid balance infusions, antibiotics infusions, nutritional infusions and other therapeutic infusions. They are mainly used to supplement body fluid, electrolytes and nutrition, and can be used as plasma substitutes to maintain blood pressure;

Oral Liquid Solution

Oral liquid/syrup is a kind of oral liquid preparation based on traditional Chinese medicine decoction, extracted from the effective ingredients of the medicine, added with additives such as flavoring agent, bacteriostantic agent, etc. Through preparation, filling and sealing, sterilization, packaging and other processes, The overall solution for the oral liquid/syrup is composed of extraction workshop, preparation workshop, packaging workshop,intelligent warehouse and other functional modules. It builds a big data integration platform for traditional Chinese medicine production which completely integrated the information of process equipment, cleanroom engineering and equipment, control system and software system into a digital pharmaceutical factory model, and realized the effective integration of all kinds of data from process equipment, production lines, workshops of the whole factory, and meet the requirements of high efficiency, high quality, safety and environmental protection in the production and operation of traditional Chinese medicine;

Solid Medicine Solution

Compared with the liquid preparations, solid preparations have the common characteristics of better physical and chemical stability, lower manufacturing cost, and convenience in taking and carrying. No matter what production process, the granulation procedures at the first stage of tablet, capsule and granule production are similar, such as mixing, granulation, drying and sorting etc. The main equipments are: granulator, grinding and granulate machine, general mixer, tablet machine / capsule filling machine, coating machine, etc.

Water Treatment & Preparation Solution

Liquid technics overall solution mainly includes liquid technic system equipment/system, liquid utilities/systems, liquid piping system and cleaning and sterilization module equipment / system. We can provide customers with cell culture and extraction, medium preparation, cleaning and sterilization, and aseptic preparation and other process systems, and purified water, injection water, pure steam and other clean utility system from many fields such as monoclonal antibody, vaccine, insulin, LVP, blood products, biological products, oral solid preparation, traditional Chinese medicine, implantable medical device, etc. Professionally provide customers with overall solutions for clean fluid processes. Liquid technics overall solution also include clean utility equipment, such as purified water machine, injection water machine, pure clean machine generator, liquid module, CIP/SIP module, biological wastewater inactivation module, temperature control module and other equipment or systems.

View All Solutions

Why Choose Us

About Marya

Engineering design team with more than 20 years of experience

Our experienced engineering team has more than 20 years experience in cleanroom design and construction. We can ensure that the process and materials for your plant are designed and manufactured in the most cost-effective manner with reliable quality, and fulfil GMP/FDA/ISO/SGS requirement.

Maryas' 3 manufacturing plants for cleanroom projects and pharmaceutical equipments are all under strict quality management systems certified to ISO9001 with a focus on continuous quality improvement.

We are experienced, professional, high-efficient and strictly sticking to the schedule. Our installation engineers and workers team have successfully installed more than 300 projects in 60 countries with high customer satisfaction.

The R&D and design personnel are composed of experienced senior engineers and technicians. We provide advanced production and testing equipment with high accuracy and onestop pre-sales and after-sales service.

Adhering to the philosophy of "client-centric", Marya creates the ultimate service experience with the heart of the craftsman. We are always on the way to create more value for our clients.

What We Have Done

case

Uruguay Antibiotic Vial Powder Filling Machine Project

The client is a pharmaceutical factory in Uruguay, which mainly produces vials/ampoules for liquid and powder preparations

Malaysia Prefilled Syringe Filling Production Line Project

What Our Clients Say

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Malaysia Client

Marya's marketing team is the best I've ever seen China in communication and service, they make everything clear and keep me updated in production and shipping progress, I will definitely keep cooperating with them.

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Zimbabwe Client

The consultation and also the responsiveness of Shanghai Marya engineers, they were always available to have an answer and also to take the productive action of any process that we concerned about, and our engineers were working with Shanghai Marya learned a lot.

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Dominica Client

Marya installation team is very commited to their work, very helpful and help us build our own installation team.

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Malaysia Client

What We Manufacture

Shanghai marya is an overall solution provider specializing in pharmaceutical machinery, engineering design, cleanroom project, project management and validation.

SVP（Small Volume Parenteral）Preparation System

SVP preparations refer to sterile liquid injectable preparations with a volume of 1-50ml, which are mainly used to inject drugs directly into the human body (such as vein, muscle or subcutaneous), with the characteristics of rapid onset, precise dosage and high bioavailability. Its production needs to meet the stringent standards of sterility, no pyrogen, and visible foreign matter control.

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Vial Liquid Filling Sealing Production Line

Marya is one of the best Liquid Vial Filling Machine manufacturers, can provide a wide range of automatic vial filling production line machines for the pharmaceutical industry. Such as vial filling and capping machine 、vial stoppering machine. Capable of handling vial sizes up to 100 ml and speeds up to 36000 per hour. Our vial filling machine can meet any requirement you need.

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Aseptic pre-filled syringe filling and sealing line

As a professional prefilled syringe filling machine manufacturers, we produce high production capacity pfs filling machines for batch filling operations. Fully automatic design, clean laminar flow protection in the whole production process, servo system control, can complete your various needs of syringe filling applications.

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Cartridge Filling Line

The cartridge filling line is composed of an ultrasonic bottle washing machine, an air-drying silicone oil injection integrated machine, a sterilization dryer, and a cartridge stoppering filling capping machine. It can complete complex functions such as spraying water, ultrasonic cleaning, air & water flushing of the inner and outer walls of cartridge bottles, air drying, silicone oil spraying, preheating, drying, and sterilization, heat source removing, cooling, stoppering, filling, capping, etc., realizing automatic production of the whole process.

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RTU Syringe Cartridge Vial Filling Machine

The pre-filled syringe filling and stoppering production line is used for the sterile filling of RTU pre-filled syringe, RTU vial, RTU cartridge, etc., can automatically complete unpacking, filling, stoppering and other process steps, and widely used in pharmaceutical, cosmetic medicine, medical and other industries.

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Ampoule Liquid Filling Sealing Production Line

The automatic Ampoule Liquid Filling Sealing Production Line is composed of ultrasonic bottle washing machine, dryer sterilizer and ampoule filling and sealing machine. It can complete spraying water, ultrasonic cleaning, air & water flushing of inner and outer wall of ampoule bottle, preheating, drying and sterilization, heat source removing, cooling, (nitrogen pre-filling), filling, (nitrogen post-filling), ampoule sealing and other complex functions, realizing automatic production of the whole process. Each machine can be used separately or in linkage line. The whole line is mainly used for ampoule injections filling in pharmaceutical factories and the general type can also be used for antibiotic vial injection filling or powder filling.

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Sterile Isolator

As a decontamination equipment separating operators and machines and complying with the requirements of Class A environment, the sterile isolator is mainly used for the protection of sterile testing, sterile product dispensing and other key process. It can reduce the background or environment requirements, improve the reliability of inspection results, meet the requirements of China GMP and Pharmacopoeia, EU GMP/FDA and cGMP/USP-NF, and can carry out "continuous" or "batch" operation.

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Negative-pressure Isolator

The negative-pressure isolator is often used for the weighing, dispensing, feeding and other operations of highly active, toxic and allergenic drugs. The operation process is isolated through the closed barrier system to protect the health of the operator. Its internal environment cleanliness is Class C and meets process and cGMP requirements. It is widely used in the fields of medical, pharmaceutical, chemical, food industries and so on.

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Linkage Production Line Isolator

The pharmaceutical isolation system is integrally installed on the sterile filling machine or other equipment to form a controlled enclosure or barrier that completely isolates operators and products. By equipping this system for sterile filling, the risk of drug contamination will be effectively reduced and the quality of drugs be greatly improved.

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GMP Cell Drug Preparation Station

The cell preparation workstation can be configured with key instruments in Class A environment according to customer process, which is ergonomic and easy to operate. It can guarantee the sterility of the whole process of cell preparation, and realize various operations such as separation and extraction. Combined with the self-developed management system, it is suitable for batch production and clinical trials of cell therapy drugs. It is a closed integrated operating system that meets the GMP sterile production requirements. Moreover, it can replace the traditional GMP laboratory and integrate multiple functional equipment to provide a sterile environment.

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LVP（Large Volume Parenteral）Preparation System

LVP Preparation refers to sterile liquid preparation administered via intravenous infusion or body cavity irrigation, packaged in single-dose containers with a nominal volume ≥100ml. It is mainly used for body fluids/electrolytes replenishment, nutritional support or disease treatment.

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CIP（Cleaning In Place）Station System

The CIP station system is a technology that cleans the equipment in situ. It is mainly used to assist the on-line cleaning of various liquid distribution systems, tanks and pipelines of bioreactor systems. By recycling specific cleaning fluids, it is efficient and comprehensive to clean the inside of production equipment without disassembly or moving equipment components.

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Shanghai marya is an overall solution provider specializing in pharmaceutical machinery, engineering design, cleanroom project, project management and validation.

SVP（Small Volume Parenteral）Preparation System

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What’s New

2025-01

Ecuador Cleanroom HVAC Project Complete Perfectly

In October 2024, the Shanghai Marya team, in close cooperation with the client, successfully completed the Ecuador solid preparation cleanroom turnkey project.

2024-06

Marya Received Industry Recognition at CPHI China 2024

At CPHI 2024, Marya was highly recognized for its outstanding products and services.

2024-06

Shanghai Marya Participates in CPHI Exhibition

This year, the CPHI China 2024 will continue to join hands with the PMEC China 2024 to present at Shanghai New International Expo Center from June 19th to June 21st. At the expo, more than 3,500 exhibitors from home and abroad will show their cases and products in the large exhibition area of 210,000 square meters.

2024-05

Marya Cleanroom Cargoes Sent to Ecuador

The cleanroom air conditioning unit of Ecuador pharmaceutical factory was successfully shipped at the end of May 2024.

Because of persistence, so we are excellent

Work with the industry's technical experts, climb the peak and create the future intelligently.

CONTACT

Shanghai Office: NO211, North Fute Road, Pudong area, Shanghai, China, 200131

Changsha Office: Room 23069, Block 6, Forte Star Shine World, Yuhua District, Changsha, Hunan province

Factory 1: Hunan Marya Technology Co., Ltd. Address: No. 7 Plant, SANY Industrial Park, No. 1, SANY Road, Changsha Pilot Free Trade Zone, Hunan Province, China, 410100

Factory 2: No 555, Yupan Road, Weitang Town, Xiangcheng District, Suzhou, Jiangsu Province, China

Factory 3: 15-A, Venture Capital Industrial Square, Yanghe Road, Suzhou Industrial Park

WhatsApp: +86-19198185202

E-Mail：info@marya.com.cn