Nasal Spray Filling Production Line
This fully automatic nasal spray filling line is a complete set of mass-production equipment, suitable for a wide range of water-based spray products including medical nasal sprays, physiological saline, nasal care solutions, and antibacterial sprays.
- Product Description
- Technical Features
- Technical Parameters
- Optional Systems
- Application Scenarios
- Video
-
Introduction
The nasal spray filling line highly integrates automated processes such as bottle unscrambling and feeding, internal and external spray washing with purified water / water for injection, far-infrared tunnel sterilization and drying, aseptic filling, capping, visual inspection and rejection, as well as labeling and coding, achieving unmanned continuous mass production. The core filling and capping stations can be equipped with Class 100 laminar flow hoods, providing ISO 5 (Grade A) unidirectional airflow aseptic clean protection, and are compatible with Grade B cleanroom environments. The complete line fully complies with the latest version of GMP pharmaceutical production regulations, meeting the high-standard production requirements for pharmaceuticals, medical devices, and export markets.
-
Washing Machine:
(1) Adopts a two-water-one-air alternating spray rinsing method, providing comprehensive bottle cleaning with no residual liquid and no dead corners.
(2) An optional ultrasonic cleaning module is available upon request, suitable for high-purity aseptic production scenarios, effectively removing particulate impurities from bottles to ensure filling cleanliness standards.
Tunnel:
(1) Equipped with far-infrared electric quartz heating tubes, offering high thermal efficiency, energy savings, and durable performance with stable sterilization and drying results.
(2) Utilizes a stainless-steel mesh belt with variable-frequency drive for smooth operation and adjustable speed, accommodating various production capacity requirements.
(3) Features a partitioned design with independent heating and cooling sections, plus a thickened aluminum silicate fiber insulation layer for effective temperature retention and lower energy consumption.
(4) Includes a dedicated top moisture-exhaust structure that rapidly removes water vapor, improving drying and sterilization efficiency and ensuring aseptic production quality.
Filling & Capping Machine:
(1) Equipped with a servo control system and high-precision photoelectric detection, intelligently implements no-filling-no-bottle, no-stoppering-no-bottle, and no-capping-no-bottle, preventing defective products at the source.
(2) Servo-driven metering pumps ensure accurate filling, combined with anti-drip suck-back technology and submerged bottom filling to minimize bubble generation, achieving high filling precision and consistent product appearance.
(3) Optional integration of CIP and SIP modules for the filling system enables in-place cleaning and sterilization.
(4) Optional nitrogen purging system effectively prevents oxidation of the product.
(5) Independent servo-driven capping with precise and adjustable torque prevents thread stripping, bottle breakage, and poor sealing.
(6) Compatible with 5–30 ml glass bottles and a variety of spray pump heads, supporting tool-free quick changeover.
(7) Integrated functions include leakage rejection, on-line seal-integrity inspection, and automatic alarm interlock shutdown in case of abnormalities.
(8) Can be equipped with laminar flow hoods or isolators to meet the aseptic production requirements of high-grade sterile workshops.
-
Items Parameters Production Capacity 10,000 – 12,000 bottles/hour Applicable 5 – 30 ml glass / plastic bottles Filling Heads 18 heads Capping Heads 12 heads Filling Accuracy ≤±1% Product Qualification Rate ≥99.9% Sterilization Temperature 300-350℃ Water Consumption 0.6-1t/h Air Consumption 20 m³/h, working pressure 0.3 – 0.6 MPa Power Supply / Total Power 220/380 V, total power ≤ 90 kW -
(1) Pharmaceutical Products
Production of sterile pharmaceutical spray formulations, including sterile saline nasal sprays, prescription nasal solutions, anti-allergic nasal preparations, and anti-inflammatory nasal care liquids.
(2) Medical Devices
Mass production of medical device products such as Class II seawater nasal irrigation solutions, children-specific nasal sprays, and physiological seawater nasal care sprays.
(3) Daily Chemical & Disinfection Products
Production of daily care spray products, including nasal moisturizing care sprays, antibacterial protective sprays, and household mild disinfection sprays.
(4) Production Scenarios
Suitable for a full range of scenarios, including GMP-certified aseptic cleanrooms, high-grade medical production workshops, standardized mass production for export markets, and OEM/ODM contract manufacturing for brand-customized batch production.
Years rich Industry Experience
Production Bases
Successful Projects in 60 Countries
Loyal Clientele
Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects
Tanzanian Vice President Visits Marya Pharmaceutical EPC Project
NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory
NOVO NORDISK client Visit
Clients visit the factory's liquid preparation system
Argentine client visits for FAT in MARYA
INTERESTED IN MARYA?
Get In Touch With Us.
We Will Be Happy To Discuss Our Solutions And Services With You.
Contact Now
Full-process Consulting Services
Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.
2D/3D Design Modeling Services
Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.
Machine Customization Services
Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.
Validation Services (FAT/SAT)
Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.
Key words:
Previous:
:Next
Contact MARYA Engineers to Claim Your Free GMP compliant Aseptic Pharmaceutical Production Line Solution
Looking for a worry-free, labor-saving, and cost-saving solution? Want to get product catalogs and price lists? Please fill out the form below or send an email and our professional team will contact you within 12 hours.
CONTACT INFO
NO211, North Fute Road, Pudong area, Shanghai, China, 200131
CONTACT
Shanghai Office: NO211, North Fute Road, Pudong area, Shanghai, China, 200131
Changsha Office: Room 23069, Block 6, Forte Star Shine World, Yuhua District, Changsha, Hunan province
Factory 1: No. 7, Building 1, No. 326 Linyu Road, Yuelu District, Changsha, Hunan, China
Factory 2: No 555, Yupan Road, Weitang Town, Xiangcheng District, Suzhou, Jiangsu Province, China
Factory 3: 15-A, Venture Capital Industrial Square, Yanghe Road, Suzhou Industrial Park
