Pharmaceutical Granulator machine
Granulator pharmaceutical machine is the operation of processing materials in the state of powder, melting liquid and aqueous solution into particles of certain shape and size. The preparation process of almost all solid preparations is inseparable from granulation process. The particles may be finished products, such as granules, or intermediate products, such as tablets.
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Basic Introduction
The common solid dosage forms are powder, granule, tablet, capsule, drop pill, film etc., which account for about 70% of pharmaceutical preparations. The common characteristics of solid preparations compared with liquid preparations, good physical and chemical stability, lower manufacturing cost, and easy to take and carry. No matter what production process, the granulation procedures at the first stage of tablet, capsule and granule production are similar, such as mixing, granulation, drying and sorting etc. The main equipment are: granulator, grinding and granulate machine, general mixer, tablet machine / capsule filling machine, coating machine, etc.
The principle of granulation:
The granulation operation makes particles have some corresponding purposes, so as to ensure product quality and smooth progress of production. For example, if particles are products in granules and capsules, the purpose of granulation is not only to improve fluidity, dispersion and adhesion of materials, and to facilitate accurate measurement and protect production environment, but also to ensure the uniform shape and size of particles, beautiful appearance and so on. In the production of tablets, particles are intermediate products, it is not only to improve fluidity to reduce weight difference of tablets, but also to ensure compression formability of particles. There are many different kinds of granulation methods, even if the same prescription, granulating content not only has different shape, size and strength, but also has different disintegration and solubility, resulting in different pesticide effect. Therefore, the suitable granulation method should be selected according to characteristics of the required particles.
The common granulation methods:
wet granulation, one-step granulation, dry granulation and spray granulation.
The purpose of granulation:
- To improve liquidity. Generally speaking, the particle size of particle is larger than one of powder, and the number of particles that can be contacted around each particle is less, so adhesion and agglutination are greatly weakened, thus greatly improving fluidity of material. Although material is solid, but it can be treated as quantitatively as liquid.
- To prevent separation of various components. It is prone to segregation when particle size and density of each component of the mixture are different, and segregation can be effectively prevented by granulation after mixing or mixing after granulation.
- Prevent dust flying and adhesion on the wall. The dust explosion and adhesion of powder are serious. After granulation, environmental pollution and the loss of raw materials can be prevented, which is beneficial to GMP management.
- Adjust packing density to improve solubility;
- Improve the uniform transmission of pressure in tablet production;
- Easy to take and carry, improve value of commodity.
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Full-process Consulting Services
Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.
2D/3D Design Modeling Services
Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.
Machine Customization Services
Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.
Validation Services (FAT/SAT)
Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.
Key words:
granulator machine
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Pharmaceutical granulating machine
Granulator
granulation machine
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