Aseptic pre-filled syringe filling and sealing line
As a professional prefilled syringe filling machine manufacturers, we produce high production capacity pfs filling machines for batch filling operations. Fully automatic design, clean laminar flow protection in the whole production process, servo system control, can complete your various needs of syringe filling applications.
- Product Description
- Technical Features
- Technical Parameters
- Optional Systems
- Application Scenarios
- Video
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1. Introduction
Aseptic pre-filled syringe filling and sealing line is mainly used for the unpacking, tearing, filling and plugging of disposable syringes in nest boxes in pharmaceutical plants. It’s mainly for the production and packaging of various aseptic products such as vaccines, monoclonal antibodies, small molecule heparin, insulin and hyaluronic acid.
2. Successful Prefilled Syringe Filling Line Case
We did a successful prefilled syringe filling line in Malaysia, click on the following link to learn more details: Malaysia-Prefilled-Syringe-Filling-Production-Line-Project
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- The design, materials, manufacturing, assembly and commissioning of the whole prefilled syringe filling line manufacturing process are in accordance with the new GMP regulations;
- These syringe liquid filling machine adopts servo control system to automatically complete the processes of honeycomb tray unpacking, tearing film, conveying, filling, plug feeding, plug filling and tray output. It’s with electromechanical integration control, stable operation and high degree of automation;
- Automatic removal and return of the syringe from the honeycomb tray by means of a servo system combined with a cylinder;
- Fully automatic production control with intelligent testing devices at the core stations;
- No friction between the contact surface of the pluger and the drug solution and the bottom rail during transport. The stopper is always protected by laminar flow, avoiding the risk of particles and contamination;
- The main drive components of the syringe filling line are servo-driven and are located in the lower part of the machine frame, which allows precise positioning and avoids pollution of the environment.
- The plastic syringe filling machine can be equipped with a servo motor controlled filling pump for filling, which is highly accurate and easy to adjust;
- Fully automatic control and monitoring of the production process using control technologies such as high-precision colour touch screen operation and monitoring, PLC automatic control, automatic protection and mainframe variable frequency speed regulation;
- Can customized relevant products according to the actual needs of the customer.
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- Applications: 1ml - 20ml (according to user specifications);
- Filling range: 0.1ml-20ml;
- Capacity: 2000-30000 bph;
- Filling head: 2-10 pcs, choose according to capacity;
- Various types of syringe filling pump options: metal pump, peristaltic pump, ceramic pump;
- PFS machine filling accuracy: ≤ ± 1% (depending on the characteristics of the medicine);
- Pass rate ≥99.9% ;
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- Configurable filling system CIP/SIP system;
- A nitrogen filling unit can be configured to isolate the medicinal solution from oxygen;
- Can be equipped with a vacuum filling system for filling the high viscous products;
- Configurable with Open-RABS isolation protection system and Class 100 air purification laminar flow system;
- The high-performance no bottle no filling, no bottle no capping and linked bottle squeeze stop function can be configured;
- Pharmaceutical syringe filling machine can be equipped with multiple robots for collaborative control technology to fully automate the process of tearing film, de-lining, filling, pluging and weighing of pre-filled syringes;
- The automatic calibration of the filling volume can be configured to calibrate the filling volume fully automated;
- Can be equipped with fully closed aseptic isolation (Isolator) systems and bag-in-bag-out (BIBO) systems if needed;
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Vaccine production: for large-scale filling needs such as COVID-19 vaccines and influenza vaccines.
Biological preparation: for filling of monoclonal antibodies, cell therapy drugs and other high-value biological preparations.
Insulin injection: to meet the precise filling requirements of diabetes treatment drugs.
Beauty and medical aesthetics: for filling of hyaluronic acid, and other medical aesthetic products.
Years rich Industry Experience
Production Bases
Successful Projects in 60 Countries
Loyal Clientele
Invited to the Embassy of the United Republic of Tanzania in Guangzhou to discuss projects
NBA (Zimbabwe National Biotechnology Authority) conducts FAT at MARYA’s Factory
NOVO NORDISK client Visit
Argentine client visits for FAT in MARYA
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Full-process Consulting Services
Whether you are preparing to build a new pharmaceutical factory, build a cleanroom that complies with local GMP regulations, or purchase pharmaceutical equipment to develop a new production line, whether it is a separate cleanroom or pharmaceutical machine project, or a one-stop solution, Marya's professional teams in the fields of pharmaceutical technical process, process equipment, decoration engineering, HVAC engineering, pipeline engineering, utility equipment, intelligent automatic control systems, project cost and other fields can provide you with full-process technical consulting services, and solve your needs one-on-one.
2D/3D Design Modeling Services
Marya project design team is composed of professional CAD and BIM engineers with more than 20 years of comprehensive industry experience and can provide you with comprehensive design services, including but not limited to process layout drawings, technical process charts, 3D models and animations, air conditioning system scheme design, construction drawing design, plant/pharmaceutical machine layout drawings, etc.
Machine Customization Services
Based on the individual needs of clients in different countries, Marya helps you clarify specific needs, match appropriate models, and customize one stop filling solutions for sterile small-volume preparations, large-volume injections, oral liquids/syrups, solid preparations, etc.
Validation Services (FAT/SAT)
Marya will appoint an engineer with rich project management experience as the person in charge, who will be fully responsible for project management and liaison work. After the equipment is manufactured, our engineers and the buyer's representatives will participate in the FAT test. After the equipment arrives at the buyer's site, it will be installed and debugged. After the equipment reaches optimal operation, the buyer will conduct SAT testing and inspection.
Key words:
plastic PFS filling machine
pre-filled syringe filling machine
syringe filling machine
PFS filling machine
syringe filling line
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CONTACT INFO
NO211, North Fute Road, Pudong area, Shanghai, China, 200131
CONTACT
Shanghai Office: NO211, North Fute Road, Pudong area, Shanghai, China, 200131
Changsha Office: Room 23069, Block 6, Forte Star Shine World, Yuhua District, Changsha, Hunan province
Factory 1: Hunan Marya Technology Co., Ltd. Address: No. 7 Plant, SANY Industrial Park, No. 1, SANY Road, Changsha Pilot Free Trade Zone, Hunan Province, China, 410100
Factory 2: No 555, Yupan Road, Weitang Town, Xiangcheng District, Suzhou, Jiangsu Province, China
Factory 3: 15-A, Venture Capital Industrial Square, Yanghe Road, Suzhou Industrial Park
