The principle of granulation:
The granulation operation makes particles have some corresponding purposes, so as to ensure product quality and smooth progress of production. For example, if particles are products in granules and capsules, the purpose of granulation is not only to improve fluidity, dispersion and adhesion of materials, and to facilitate accurate measurement and protect production environment, but also to ensure the uniform shape and size of particles, beautiful appearance and so on. In the production of tablets, particles are intermediate products, it is not only to improve fluidity to reduce weight difference of tablets, but also to ensure compression formability of particles. There are many different kinds of granulation methods, even if the same prescription, granulating content not only has different shape, size and strength, but also has different disintegration and solubility, resulting in different pesticide effect. Therefore, the suitable granulation method should be selected according to characteristics of the required particles.
The common granulation methods:
Wet granulation, one-step granulation, dry granulation and spray granulation.
The purpose of granulation:
a、To improve liquidity. Generally speaking, the particle size of particle is larger than one of powder, and the number of particles that can be contacted around each particle is less, so adhesion and agglutination are greatly weakened, thus greatly improving fluidity of material. Although material is solid, but it can be treated as quantitatively as liquid.
b、To prevent separation of various components. It is prone to segregation when particle size and density of each component of the mixture are different, and segregation can be effectively prevented by granulation after mixing or mixing after granulation.
c、Prevent dust flying and adhesion on the wall. The dust explosion and adhesion of powder are serious. After granulation, environmental pollution and the loss of raw materials can be prevented, which is beneficial to GMP management.
d、Adjust packing density to improve solubility;
e、Improve the uniform transmission of pressure in tablet production;
f、Easy to take and carry, improve value of commodity.
Products that maybe needed
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